In 1995, Kramer et al showed that a subset of dogs with DCM, in which golden retrievers and American cocker spaniels were overrepresented, had taurine deficiency. Less intuitive was the discovery that taurine deficiency also leads to DCM in the dog, despite the fact that taurine is not considered an essential amino acid in this species. Due to low enzyme activities of this pathway, which limit endogenous synthesis, taurine is nutritionally essential in the cat, and deficiency was easily and widely accepted as a direct cause of DCM in this species. In the dog, this sulfur-containing amino acid is synthesized primarily in the liver and central nervous system from methionine and cysteine via the transsulfuration pathway. Taurine deficiency and its association with dilated cardiomyopathy (DCM) is well described in the cat and dog. This does not alter our adherence to PLOS ONE policies on sharing data and materials. This did not lead to any conflict of interest or influence the collection or interpretation of results in this study. Fascetti is the Scientific Director of the Amino Acid Laboratory at the University of California, Davis that provides amino acid analysis on a fee for service basis. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript.įunding: The authors received no specific funding for this work.Ĭompeting interests: A.J. Received: AugAccepted: NovemPublished: December 13, 2018Ĭopyright: © 2018 Kaplan et al. Loor, University of Illinois, UNITED STATES

(2018) Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets. Citation: Kaplan JL, Stern JA, Fascetti AJ, Larsen JA, Skolnik H, Peddle GD, et al.

Taurine deficiency in dogs grain free